Research Articles
xCell 2.0: A Comprehensive Guide to Tumor Microenvironment Deconvolution for Cancer Research and Therapy Development
This article provides a detailed exploration of the xCell algorithm and its advanced version, xCell 2.0, for digital dissection of the tumor microenvironment (TME) from bulk transcriptomics data.
Visualizing the Unseen: Live Imaging Approaches to Decipher Emergent Metastatic Features
Metastasis remains the primary cause of cancer-related mortality, yet its initial stages are notoriously difficult to observe.
Voronoi Tessellation Cellular Automaton Models: From Tumor Simulation to Clinical Translation
This article comprehensively reviews the development, application, and clinical potential of Voronoi Tessellation-based Cellular Automaton (VTCA) models in oncology.
The 3MIC Ex Vivo Model: Visualizing and Targeting the Tumor Microenvironment for Metastasis Research
This article explores the 3D Microenvironment Chamber (3MIC), a transformative ex vivo model designed to directly observe and perturb the early metastatic process.
Cellular Automaton Modeling of Invasive Tumor Growth: From Theoretical Foundations to Clinical Forecasting
This comprehensive review explores the application of cellular automaton (CA) models to simulate invasive tumor growth dynamics, addressing the critical need for predictive tools in oncology.
Emergent Behavior in 3D Tumor Spheroids: From Complex Dynamics to Clinical Translation
This article provides a comprehensive analysis of emergent behaviors in 3D tumor spheroid models, which bridge the critical gap between traditional 2D cultures and in vivo studies.
Ischemic Drivers of Metastasis: Mechanisms, Models, and Therapeutic Opportunities
This article explores the critical role of ischemic conditions—hypoxia, nutrient starvation, and acidosis—in driving cancer metastasis.
Emergent Behaviors in Glioblastoma Multiforme Invasion: Decoding Cellular States, Microenvironment Crosstalk, and Therapeutic Implications
This review synthesizes current research on the emergent behaviors driving glioblastoma (GBM) invasion, a primary cause of therapeutic failure and mortality.
Cell-Cell Adhesion in Cancer: Orchestrating Phenotypic Plasticity, Therapy Resistance, and Metastasis
This review synthesizes current knowledge on the dynamic role of cell-cell adhesion in driving emergent tumor phenotypes.
Metabolic Gradients in the Tumor Microenvironment: Emergence, Function, and Therapeutic Targeting
This article provides a comprehensive analysis of the formation and functional impact of metabolic gradients within the tumor microenvironment (TME).