Research Articles
Beyond the 5% Myth: A Strategic Guide to Mitochondrial Thresholds for scRNA-seq Quality Control
This article provides a comprehensive guide for researchers and drug development professionals on the critical yet nuanced role of mitochondrial thresholding in single-cell RNA-sequencing quality control.
Overcoming PCR Bias: A Comprehensive Guide to UMI Error Correction for Accurate Transcriptomics
This article provides researchers and drug development professionals with a current and comprehensive guide to Unique Molecular Identifier (UMI) technologies for correcting PCR amplification bias in high-throughput sequencing.
Strategies for Single-Cell Whole-Genome Amplification Bias Reduction: A Comprehensive Guide for Researchers
Single-cell whole-genome amplification (scWGA) is a transformative technology enabling genomic analysis at the ultimate resolution, but its utility is constrained by technical biases including uneven genome coverage, allelic imbalance, and...
A Comprehensive Guide to Doublet Removal for Single-Cell RNA-Seq Quality Control
This article provides a complete framework for understanding and implementing doublet removal in single-cell RNA sequencing data analysis.
A Comprehensive Guide to Batch Effect Correction in Multi-Sample scRNA-seq Using Harmony
This article provides a complete resource for researchers and scientists performing single-cell RNA sequencing analysis.
Navigating the Computational Maze: Overcoming Key Challenges in Single-Cell Sequencing Data Analysis
Single-cell RNA sequencing (scRNA-seq) has revolutionized biomedical research by enabling the dissection of gene expression at unprecedented resolution, but it generates complex, high-dimensional data posing significant computational challenges.
Single-Cell TCR Sequencing in Cancer Immunotherapy: Decoding the T-Cell Repertoire for Precision Oncology
This article provides a comprehensive overview of single-cell T-cell receptor (TCR) sequencing and its transformative role in tumor immunology and immunotherapy development.
Single-Cell Epigenomic Profiling in Cancer: Decoding DNA Methylation for Precision Oncology
This article explores the transformative impact of single-cell epigenomic profiling on cancer research and drug development.
Circulating Tumor Cell Isolation and Genomic Analysis: Advanced Strategies for Researchers and Drug Developers
This article provides a comprehensive resource for researchers, scientists, and drug development professionals on the latest advancements and methodologies in circulating tumor cell (CTC) isolation and genomic analysis.
Decoding Cancer Dynamics: A Comprehensive Guide to RNA Velocity in Single-Cell Analysis
This article provides researchers, scientists, and drug development professionals with a comprehensive overview of RNA velocity and its transformative application in single-cell cancer research.