Research Articles
Calibrating Ex Vivo Metabolic Gradients: A Framework for Predictive Tumor Modeling and Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on calibrating metabolic gradients in ex vivo models.
Optimizing Stromal Score Calculation: From Foundational Principles to AI-Driven Clinical Applications
This comprehensive review addresses the critical need for optimized stromal scoring methodologies in oncology research and drug development.
Validating TME-Related Gene Signatures: From Biomarker Discovery to Clinical Application in Cancer
This comprehensive review explores the evolving landscape of tumor microenvironment (TME) gene signature validation for cancer research and therapeutic development.
Beyond the Mouse: Addressing Species Mismatch in Animal Models with Human-Relevant New Approach Methodologies
This article examines the critical challenge of species mismatch in biomedical research, where traditional animal models often fail to accurately predict human responses.
Optimizing Oxygen Gradient Tumor Models: From Physiological Relevance to Clinical Translation
This article provides a comprehensive guide for researchers and drug development professionals on optimizing oxygen gradient models for cancer research.
Improving Reproducibility in 3D Tumor Spheroids: A Strategic Guide for Robust Preclinical Models
Three-dimensional tumor spheroids have emerged as a critical in vitro tool that bridges the gap between traditional 2D cell cultures and in vivo models, offering superior physiological relevance for cancer...
Strategies for Reducing Grid Anisotropy in Cellular Automaton Models: From Foundations to Biomedical Applications
This article provides a comprehensive examination of grid anisotropy, a pervasive numerical artifact in Cellular Automaton (CA) simulations that causes unrealistic orientation-dependent growth patterns and compromises result reliability.
Visualizing Metastasis: How 3D Microenvironment Chambers are Revolutionizing Cancer Research
This article explores the transformative role of advanced 3D microenvironment chambers, such as the 3MIC, in visualizing and understanding the early stages of cancer metastasis.
CIBERSORT: A Comprehensive Guide to Tumor Microenvironment Immune Infiltration Analysis for Cancer Research
This article provides a comprehensive overview of CIBERSORT, a computational method for deconvoluting tumor immune infiltration from bulk tissue gene expression profiles.
Decoding the Tumor Microenvironment: A Comprehensive Guide to the ESTIMATE Algorithm in Cancer Research
This article provides a comprehensive exploration of the ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data) algorithm, a pivotal bioinformatics tool for deciphering tumor...