Research Articles
Performance Validation of ctDNA Assays: Technical Standards, Clinical Applications, and Future Directions for Oncology Research
This article provides a comprehensive overview of the performance validation of circulating tumor DNA (ctDNA) assays, a critical component for their reliable integration into oncology research and drug development.
Precision Quantification: Leveraging ddPCR for Optimal NGS Library Preparation
Accurate quantification of next-generation sequencing (NGS) libraries is a critical, yet often overlooked, step that directly impacts sequencing success, cost-efficiency, and data quality.
Inter-Platform Reproducibility of ddPCR: A Comprehensive Guide for Robust Biomolecular Quantification
This article provides a systematic examination of the inter-platform reproducibility of droplet digital PCR (ddPCR), a critical factor for its application in biomedical research and drug development.
dPCR vs qPCR for ctDNA Quantification: A Strategic Guide for Precision Oncology Research
This article provides a comprehensive comparison of digital PCR (dPCR) and quantitative PCR (qPCR) for the analysis of circulating tumor DNA (ctDNA), a critical biomarker in liquid biopsy.
ddPCR and Tissue Biopsy Concordance: Validating Liquid Biopsy for Precision Oncology
This article explores the established and emerging evidence for the concordance between droplet digital PCR (ddPCR) and tissue biopsy in detecting tumor-derived genetic alterations.
ddPCR vs. NGS in Liquid Biopsy: A Comprehensive Cost and Performance Analysis for Research and Drug Development
This article provides a detailed comparison of droplet digital PCR (ddPCR) and Next-Generation Sequencing (NGS) for liquid biopsy applications, focusing on cost, performance, and suitability for research and drug development.
Preserving ctDNA Integrity: A Comprehensive Guide to Sample Storage Conditions for Reliable Liquid Biopsy Results
This article provides a detailed examination of sample storage conditions critical for maintaining circulating tumor DNA (ctDNA) stability in liquid biopsy applications.
Digital PCR vs. NGS: A Strategic Guide to Sensitivity and Application Selection
This article provides a comparative analysis of digital PCR (dPCR) and Next-Generation Sequencing (NGS) for researchers and drug development professionals.
ddPCR vs NGS for ctDNA Analysis: A Technical Guide for Researchers and Drug Developers
This article provides a comprehensive comparison of droplet digital PCR (ddPCR) and next-generation sequencing (NGS) for circulating tumor DNA (ctDNA) analysis, crucial for precision oncology.
Mastering Threshold Setting for Rare Mutation Detection: From NGS Methods to Clinical Applications
This article provides a comprehensive guide for researchers and drug development professionals on establishing robust analytical thresholds for rare mutation detection.