Research Articles
Strategies for Reducing Grid Anisotropy in Cellular Automaton Models: From Foundations to Biomedical Applications
This article provides a comprehensive examination of grid anisotropy, a pervasive numerical artifact in Cellular Automaton (CA) simulations that causes unrealistic orientation-dependent growth patterns and compromises result reliability.
Visualizing Metastasis: How 3D Microenvironment Chambers are Revolutionizing Cancer Research
This article explores the transformative role of advanced 3D microenvironment chambers, such as the 3MIC, in visualizing and understanding the early stages of cancer metastasis.
CIBERSORT: A Comprehensive Guide to Tumor Microenvironment Immune Infiltration Analysis for Cancer Research
This article provides a comprehensive overview of CIBERSORT, a computational method for deconvoluting tumor immune infiltration from bulk tissue gene expression profiles.
Decoding the Tumor Microenvironment: A Comprehensive Guide to the ESTIMATE Algorithm in Cancer Research
This article provides a comprehensive exploration of the ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data) algorithm, a pivotal bioinformatics tool for deciphering tumor...
xCell 2.0: A Comprehensive Guide to Tumor Microenvironment Deconvolution for Cancer Research and Therapy Development
This article provides a detailed exploration of the xCell algorithm and its advanced version, xCell 2.0, for digital dissection of the tumor microenvironment (TME) from bulk transcriptomics data.
Visualizing the Unseen: Live Imaging Approaches to Decipher Emergent Metastatic Features
Metastasis remains the primary cause of cancer-related mortality, yet its initial stages are notoriously difficult to observe.
Voronoi Tessellation Cellular Automaton Models: From Tumor Simulation to Clinical Translation
This article comprehensively reviews the development, application, and clinical potential of Voronoi Tessellation-based Cellular Automaton (VTCA) models in oncology.
The 3MIC Ex Vivo Model: Visualizing and Targeting the Tumor Microenvironment for Metastasis Research
This article explores the 3D Microenvironment Chamber (3MIC), a transformative ex vivo model designed to directly observe and perturb the early metastatic process.
Cellular Automaton Modeling of Invasive Tumor Growth: From Theoretical Foundations to Clinical Forecasting
This comprehensive review explores the application of cellular automaton (CA) models to simulate invasive tumor growth dynamics, addressing the critical need for predictive tools in oncology.
Emergent Behavior in 3D Tumor Spheroids: From Complex Dynamics to Clinical Translation
This article provides a comprehensive analysis of emergent behaviors in 3D tumor spheroid models, which bridge the critical gap between traditional 2D cultures and in vivo studies.