Research Articles
Digital PCR Principles and Applications: A Comprehensive Guide for Biomedical Research
Digital PCR (dPCR), the third generation of PCR technology, enables absolute quantification of nucleic acids by partitioning samples into thousands of individual reactions.
Liquid Biopsy vs Tissue Biopsy in Oncology: A Strategic Guide for Research and Drug Development
This article provides a comprehensive analysis of liquid and tissue biopsy for researchers and drug development professionals.
Circulating Tumor DNA: Release Mechanisms, Analytical Techniques, and Clinical Translation in Modern Oncology
This article provides a comprehensive exploration of circulating tumor DNA (ctDNA), covering its fundamental biology and the mechanisms by which it is released into the circulation.
Circulating Tumor DNA: A Comprehensive Guide to Biology, Detection, and Clinical Applications in Precision Oncology
This article provides a comprehensive overview of circulating tumor DNA (ctDNA), a cornerstone of liquid biopsy in precision oncology.
Cancer Stem Cells: Decoding Their Central Role in Tumor Heterogeneity and Therapeutic Resistance
Cancer stem cells (CSCs) are a pivotal subpopulation driving tumor initiation, progression, and relapse due to their self-renewal capacity, differentiation potential, and profound resistance to conventional therapies.
Validation of Biomarkers to Predict Immunotherapy Response: A Comprehensive Guide from Discovery to Clinical Application
This article provides a comprehensive roadmap for researchers and drug development professionals on the validation of predictive biomarkers for cancer immunotherapy.
The Dynamic Tumor Microenvironment: Decoding Its Multifaceted Impact on Cancer Cell Behavior and Therapy
This article provides a comprehensive overview of the latest research on the tumor microenvironment (TME) and its profound influence on cancer cell behavior, progression, and therapeutic response.
Comparative Performance of PD-L1 Immunohistochemistry Assays: A Critical Analysis for Researchers and Drug Developers
This article provides a comprehensive analysis of the comparative performance of various PD-L1 immunohistochemistry (IHC) assays, a critical predictive biomarker for immune checkpoint inhibitor response.
Ensuring Equity in Early Detection: A Comprehensive Guide to Validating Cancer Risk Models Across Diverse Populations
This article addresses the critical challenge of validating cancer risk prediction models across racially, ethnically, and geographically diverse populations—a prerequisite for equitable clinical application.
Comparative Analysis of Molecular Techniques in Cancer Diagnostics: From Foundational Methods to AI-Integrated Platforms
This comprehensive review systematically compares established and emerging molecular techniques for cancer diagnostics, addressing the needs of researchers, scientists, and drug development professionals.